Effective Aggregation and Querying of Probabilistic RFID Data in a Location Tracking Context

RFID applications usually rely on RFID deployments to manage high-level events such as tracking the location that products visit for supply-chain management, localizing intruders for alerting services, and so on. However, transforming low-level streams into high-level events poses a number of challenges. In this paper, we deal with the well known issues of data redundancy and data-information mismatch: we propose an on-line summarization mechanism that is able to provide small space representation for massive RFID probabilistic data streams while preserving the meaningfulness of the information. We also show that common information needs, i.e. detecting complex events meaningful to applications, can be effectively answered by executing temporal probabilistic SQL queries directly on the summarized data. All the techniques presented in this paper are implemented in a complete framework and successfully evaluated in real-world location tracking scenarios

An HMM–ensemble approach to predict severity progression of ICU treatment for hospitalized Covid–19 patients

COVID–19–related pneumonia requires different modalities of Intensive Care Unit (ICU) interventions at different times to facilitate breathing, depending on severity progression. The ability for clinical staff to predict how patients admitted to hospital will require more or less ICU treatment on a daily basis is critical to ICU management. For real datasets that are sparse and incomplete and where the most important state transitions (dismissal, death) are rare, a standard Hidden Markov Model (HMM) approach is insufficient, as it is prone to overfitting. In this paper we propose a more sophisticated ensemble-based approach that involves training multiple HMMs, each specialized in a subset of the state transitions, and then selecting the more plausible predictions either by selecting or combining the models. We have validated the approach on a live dataset of about 1,000 patients from a partner hospital. Our results show that rare events, as well as the transitions to the most severe treatments outperform state of the art approaches

No users no dataspaces! Query-driven dataspace orchestration

Data analysis in rich spaces of heterogeneous data sources is an increasingly common activity. Examples include querying the web of linked data and personal information management. Such analytics on dataspaces is often iterative and dynamic, in an open-ended interaction between discovery and data orchestration. The current state of the art in integration and orchestration in dataspaces is primarily geared towards close-ended analysis, targeting the discovery of stable data mappings or one-time, pay-as-you-go ad hoc data mappings. The perspective here is dataspace-centric. In this paper, we propose a shift to a user-centric perspective on dataspace orchestration. We outline basic conceptual and technical challenges in supporting data analytics which is open-ended and always evolving, as users respond to new discoveries and connections

Approximating expressive queries on graph-modeled data: The GeX approach

We present the GeX (Graph-eXplorer) approach for the approximate matching of complex queries on graph-modeled data. GeX generalizes existing approaches and provides for a highly expressive graph-based query language that supports queries ranging from keyword-based to structured ones. The GeX query answering model gracefully blends label approximation with structural relaxation, under the primary objective of delivering meaningfully approximated results only. GeX implements ad-hoc data structures that are exploited by a top-k retrieval algorithm which enhances the approximate matching of complex queries. An extensive experimental evaluation on real world datasets demonstrates the efficiency of the GeX query answering

Dealing with data and software interoperability issues in digital factories

The digital factory paradigm comprises a multi-layered integration of the information related to various activities along the factory and product lifecycle manufacturing related resources. A central aspect of a digital factory is that of enabling the product lifecycle stakeholders to collaborate through the use of software solutions. The digital factory thus expands outside the actual company boundaries and offers the opportunity for the business and its suppliers to collaborate on business processes that affect the whole supply chain. This paper discusses an interoperability architecture for digital factories. To this end, it delves into the issue by analysing the main challenges that must be addressed to support an integrated and scalable factory architecture characterized by access to services, aggregation of data, and orchestration of production processes. Then, it revises the state of the art in the light of these requirements and proposes a general architectural framework conjugating the most interesting features of serviceoriented architectures and data sharing architectures. The study is exemplified through a case study

Data-driven, AI-based clinical practice: experiences, challenges, and research directions

Clinical practice is evolving rapidly, away from the traditional but inefficient detect-and-cure approach, and towards a Preventive, Predictive, Personalised and Participative (P4) vision that focuses on extending people’s wellness state. This vision is increasingly data-driven, AI-based, and is underpinned by many forms of "Big Health Data" including periodic clinical assessments and electronic health records, but also using new forms of self-assessment, such as mobile-based questionnaires and personal wearable devices. Over the last few years, we have been conducting a fruitful research collaboration with the Infectious Disease Clinic of the University Hospital of Modena having the main aim of exploring specific opportunities offered by data-driven AI-based approaches to support diagnosis, hospital organization and clinical research. Drawing from this experience, in this paper we provide an overview of the main research challenges that need to be addressed to design and implement data-driven healthcare applications. We present concrete instantiations of these challenges in three real-world use cases and summarise the specific solutions we devised to address them and, finally, we propose a research agenda that outlines the future of research in this field

Data-Driven, AI-Based Clinical Practice:Experiences, Challenges, and Research Directions

Clinical practice is evolving rapidly, away from the traditional but inefficient detect-and-cure approach, and towards a Preventive, Predictive, Personalised and Participative (P4) vision that focuses on extending people's wellness state. This vision is increasingly data-driven, AI-based, and is underpinned by many forms of "Big Health Data" including periodic clinical assessments and electronic health records, but also using new forms of self-assessment, such as mobile-based questionnaires and personal wearable devices. Over the last few years, we have been conducting a fruitful research collaboration with the Infectious Disease Clinic of the University Hospital of Modena having the main aim of exploring specific opportunities offered by data-driven AI-based approaches to support diagnosis, hospital organization and clinical research. Drawing from this experience, in this paper we provide an overview of the main research challenges that need to be addressed to design and implement data-driven healthcare applications. We present concrete instantiations of these challenges in three real-world use cases and summarise the specific solutions we devised to address them and, finally, we propose a research agenda that outlines the future of research in this field.</p

Dynamic digital factories for agile supply chains: An architectural approach

Digital factories comprise a multi-layered integration of various activities along the factories and product lifecycles. A central aspect of a digital factory is that of enabling the product lifecycle stakeholders to collaborate through the use of software solutions. The digital factory thus expands outside the company boundaries and offers the opportunity to collaborate on business processes affecting the whole supply chain. This paper discusses an interoperability architecture for digital factories. To this end, it delves into the issue by analysing the key requirements for enabling a scalable factory architecture characterized by access to services, aggregation of data, and orchestration of production processes. Then, the paper revises the state-of-the-art w.r.t. these requirements and proposes an architectural framework conjugating features of both service-oriented and data-sharing architectures. The framework is exemplified through a case study

Real-world data mining meets clinical practice: Research challenges and perspective

As Big Data Analysis meets healthcare applications, domain-specific challenges and opportunities materialize in all aspects of data science. Advanced statistical methods and Artificial Intelligence (AI) on Electronic Health Records (EHRs) are used both for knowledge discovery purposes and clinical decision support. Such techniques enable the emerging Predictive, Preventative, Personalized, and Participatory Medicine (P4M) paradigm. Working with the Infectious Disease Clinic of the University Hospital of Modena, Italy, we have developed a range of Data-Driven (DD) approaches to solve critical clinical applications using statistics, Machine Learning (ML) and Big Data Analytics on real-world EHRs. Here, we describe our perspective on the challenges we encountered. Some are connected to medical data and their sparse, scarce, and unbalanced nature. Others are bound to the application environment, as medical AI tools can affect people's health and life. For each of these problems, we report some available techniques to tackle them, present examples drawn from our experience, and propose which approaches, in our opinion, could lead to successful real-world, end-to-end implementations. DESY report number: DESY-22-153

miRNAs Copy Number Variations Repertoire as Hallmark Indicator of Cancer Species Predisposition

Aging is one of the hallmarks of multiple human diseases, including cancer. We hypothesized that variations in the number of copies (CNVs) of specific genes may protect some long-living organisms theoretically more susceptible to tumorigenesis from the onset of cancer. Based on the statistical comparison of gene copy numbers within the genomes of both cancer-prone and -resistant species, we identified novel gene targets linked to tumor predisposition, such as CD52, SAT1 and SUMO. Moreover, considering their genome-wide copy number landscape, we discovered that microRNAs (miRNAs) are among the most significant gene families enriched for cancer progression and predisposition. Through bioinformatics analyses, we identified several alterations in miRNAs copy number patterns, involving miR-221, miR-222, miR-21, miR-372, miR-30b, miR-30d and miR-31, among others. Therefore, our analyses provide the first evidence that an altered miRNAs copy number signature can statistically discriminate species more susceptible to cancer from those that are tumor resistant, paving the way for further investigations.Aging is one of the hallmarks of multiple human diseases, including cancer. We hypothesized that variations in the number of copies (CNVs) of specific genes may protect some long-living organisms theoretically more susceptible to tumorigenesis from the onset of cancer. Based on the statistical comparison of gene copy numbers within the genomes of both cancer-prone and-resistant species, we identified novel gene targets linked to tumor predisposition, such as CD52, SAT1 and SUMO. Moreover, considering their genome-wide copy number landscape, we discovered that microRNAs (miRNAs) are among the most significant gene families enriched for cancer progression and predisposition. Through bioinformatics analyses, we identified several alterations in miRNAs copy number patterns, involving miR-221, miR-222, miR-21, miR-372, miR-30b, miR-30d and miR-31, among others. Therefore, our analyses provide the first evidence that an altered miRNAs copy number signature can statistically discriminate species more susceptible to cancer from those that are tumor resistant, paving the way for further investigations